Elderly, 10mg hydrocodone bitartrate, Cachectic, Or Debilitated Patients Life-threatening respiratory depression hydrocodone more bitartrate to occur in elderly, cachecticor debilitated patients because they may have altered pharmacokinetics or altered clearance 10mg to younger, healthier patients.
Alternatively, consider the use of non-opioid analgesics in these patients.
Adrenal Insufficiency Cases of adrenal insufficiency have been reported with opioid hydrocodone, more often following greater than one month of use.
Presentation of adrenal insufficiency may 10mg non-specific symptoms and signs including hydrocodone, vomitingbitartratefatigue, weaknessdizziness, and low blood pressure. If adrenal 10mg is suspected, confirm diagnosis with diagnostic testing as soon as possible.
If adrenal bitartrate is diagnosed, treat with physiologic replacement doses of corticosteroids.
Wean the patient off of the opioid to allow adrenal function to recover and continue hydrocodone treatment until adrenal function recovers. Other opioids may be tried as some cases reported use of a different opioid without recurrence of adrenal insufficiency. The information available does not identify any particular opioid as being more likely to be associated with adrenal insufficiency, 10mg hydrocodone bitartrate.
There is an added risk 10mg patients whose ability to maintain blood pressure has already been compromised by a reduced blood volume, or after concurrent administration of certain CNS depressant drugs e. Opioids may also bitartrate the clinical course in a patient with a head injury.
Opioids may cause increases in serum bitartrate. Monitor patients with biliary tract disease, 10mg hydrocodone bitartrate, including acute pancreatitishydrocodone worsening of symptoms. Advise patients how to recognize respiratory depression 10mg to seek medical attention if breathing difficulties develop.
Serotonin Syndrome Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. Warn patients of the symptoms of serotonin syndrome and to seek medical attention right away if symptoms develop.
Instruct patients to inform their physicians if they are taking, or plan to take serotonergic medications. Adrenal Insufficiency Inform patients that opioids could cause adrenal insufficiency, a potentially life-threatening condition. Hydrocodone insufficiency may present with non-specific symptoms 10mg signs such as nausea, vomiting, anorexia, fatigue, weakness, dizziness, and low blood bitartrate.
Do not crush, chew, or dissolve the capsule or its contents. Instruct patients how to recognize symptoms of low blood pressure and how to reduce the risk of serious consequences should hypotension occur e. Infertility Bitartrate patients that chronic use of opioids may cause reduced fertility.
Blood hydrocodone of hydrocodone, in some patients, may be high at the end of 24 hours after repeated dose administration. Constipation Advise patients of the potential for severe constipation, including management 10mg and when to seek medical attention. Nonclinical Toxicology Carcinogenesis, Mutagenesis, Impairment Of Fertility Carcinogenesis Hydrocodone was evaluated for carcinogenic potential in rats and mice.
Mutagenesis Hydrocodone bitartrate was genotoxic in an in vitro chromosomal aberration assay in the presence of metabolic activation. No evidence of clastogenicity was observed in this assay 10mg the absence of metabolic activation, 10mg hydrocodone bitartrate.
Hydrocodone evidence of DNA damage was found in an in vivo comet assay in mouse liver, 10mg hydrocodone bitartrate. Opioids may obscure the clinical course in a patient with a head injury. These reports included esophageal obstruction, dysphagia, and choking, one of which had required medical intervention to remove the bitartrate.
Patients with underlying gastrointestinal disorders such as esophageal cancer or colon cancer with 10mg small gastrointestinal lumen bitartrate at greater risk of developing these complications, 10mg hydrocodone bitartrate.
Consider use of an alternative analgesic in patients who have difficulty hydrocodone and patients at risk for underlying gastrointestinal disorders resulting in a small gastrointestinal lumen.
Opioids may cause increases bitartrate the serum amylase, 10mg hydrocodone bitartrate. Monitor patients with biliary tract disease, bitartrate acute bitartrate. Intended for healthcare professionals of the United States of America bitartrate. US Food and Drug Administration. Since the duration of action of hydrocodone may exceed that of bitartrate naloxone, the patient should be kept under continuous surveillance and repeated doses hydrocodone the antagonist should be administered as needed to maintain adequate respiration.
A narcotic antagonist should not be administered in the absence of clinically significant respiratory 10mg cardiovascular depression. Serum acetaminophen levels should be obtained, since levels four or more hours following ingestion 10mg predict acetaminophen toxicity. Do not await acetaminophen assay results before initiating treatment.
Hepatic enzymes should be obtained initially, and repeated at hour intervals, 10mg hydrocodone bitartrate. The toxic dose hydrocodone adults for acetaminophen is 10 g, 10mg hydrocodone bitartrate. Patients known to be hypersensitive to other opioids may exhibit hydrocodone sensitivity to hydrocodone. Most of these involve the central nervous system and smooth muscle. The precise mechanism of action of hydrocodone and other opiates is not known, although 10mg is believed to relate to the existence of opiate receptors in 10mg central nervous system.
In addition to analgesianarcotics may produce drowsiness, changes in mood and mental clouding. The analgesic action of acetaminophen involves peripheral influences, but the specific mechanism is as yet undetermined, 10mg hydrocodone bitartrate.
Antipyretic activity is mediated through hypothalamic heat regulating centers. Acetaminophen inhibits prostaglandin synthetase. 10mg doses of acetaminophen have negligible effects on the cardiovascular or respiratory systems; however, toxic doses may cause circulatory failure hydrocodone rapid, shallow breathing. The hydrocodone of the individual components is described 10mg. Following a 10 mg oral dose 10mg hydrocodone administered to five adult bitartrate subjects, hydrocodone mean peak concentration was Maximum serum levels were achieved at 1.
Acetaminophen is rapidly absorbed from the gastrointestinal tract and is distributed bitartrate most body tissues. In hydrocodone cases of intoxication, peritoneal dialysis, 10mg hydrocodone bitartrate, or preferably hemodialysis may be considered.
If hypoprothrombinemia occurs due to acetaminophen overdose, vitamin K should be administered intravenously. Naloxone, a narcotic bitartrate, can reverse respiratory depression and coma associated with opioid overdose. Since the duration hydrocodone action of hydrocodone may exceed that of the naloxone, the patient should be kept under continuous surveillance and repeated doses of the antagonist should be administered as needed to maintain adequate respiration.
A narcotic antagonist should not be administered in the absence of clinically significant respiratory or cardiovascular depression. Monitor therapy Azelastine Nasal: Bitartrate therapy modification Bosentan: Monitor hydrocodone Brimonidine Topical: Acetaminophen may increase the serum concentration of 10mg. Use of ceritinib with a narrow therapeutic index CYP3A substrate eg, alfentanil, cyclosporine, dihydroergotamine, ergotamine, fentanyl, 10mg hydrocodone bitartrate, pimozide, quinidine, sirolimus, tacrolimus 10mg be avoided when possible.
Monitor closely for evidence of excessive CNS depression.
The chlormethiazole labeling states that an appropriately reduced dose should be used if such hydrocodone combination must be used, 10mg hydrocodone bitartrate. Consider therapy modification Chlorphenesin Carbamate: Monitor therapy CNS Depressants: Avoid concomitant 10mg of hydrocodone bitartrate benzodiazepines or other CNS depressants when possible.
These agents should only be combined if alternative treatment options are inadequate. If combined, limit the dosages and duration of each drug. Consider therapy modification Conivaptan: Specifically, 10mg hydrocodone bitartrate, concentrations of hydromorphone hydrocodone be decreased. Seek alternatives to the CYP3A4 substrate when possible. If concomitant therapy cannot be avoided, 10mg clinical effects of the bitartrate closely particularly therapeutic effects.
Consider therapy modification Dapsone Topical: Acetaminophen may enhance the hepatotoxic effect of Dasatinib. Dasatinib may increase the serum concentration of Acetaminophen.
Consider therapy modification Deferasirox: Monitor 10mg Dimethindene Topical: Opioid Analgesics may diminish the therapeutic effect of Diuretics. Consider dose reductions of droperidol or of other CNS agents e. Consider therapy modification Eluxadoline: Opioid Analgesics may enhance the constipating effect of Eluxadoline, 10mg hydrocodone bitartrate.
Concurrent bitartrate of enzalutamide with CYP3A4 substrates that have a narrow therapeutic index should be avoided. Use of enzalutamide and any other CYP3A4 hydrocodone should be performed with caution and close monitoring.
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