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© Copyright 2017 Norgestrel-ethinyl estradiol reviews - Ethinyl estradiol and norgestrel is a combination drug that contains female hormones that prevent ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus..