Promethazine may mask the warning signs of ototoxicity caused by ototoxic drugs e. It may also delay the early diagnosis of intestinal obstruction or raised intracranial pressure through the suppression of vomiting.
Patients secundarios rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.
Phenergan should not be used for longer than 7 days without seeking medical advice, phenergan 50 mg efectos secundarios. Alcohol should be avoided during treatment. Phenergan may interfere with immunological urine pregnancy tests to produce false-positive or false-negative results. Phenergan should be efectos at least 72 hours before the start of skin tests as it may phenergan the cutaneous histamine response secundarios producing false-negative results. The use phenergan Phenergan is not recommended in the 2 weeks prior to delivery in view of the risk of irritability and excitement in the neonate, phenergan 50 mg efectos secundarios.
Available evidence suggests that the amount excreted in milk is insignificant. However, there are risks of efectos irritability and excitement. Side effects may be seen in a few patients: Anticholinergic side effects such as blurred vision, dry mouth and urinary retention occur occasionally. Infants are susceptible to the anticholinergic effects of promethazine, while other children may display paradoxical hyperexcitability. The elderly are particularly susceptible to phenergan anticholinergic effects and confusion due to promethazine.
Other side-effects include urticaria, rash, pruritus, anorexia, gastric irritation, palpitations, hypotension, arrhythmias, extrapyramidal effects, muscle spasms and tic-like movements of the head and face, phenergan 50 mg efectos secundarios. Anaphylaxis, jaundice and blood dyscrasias including haemolytic anaemia secundarios occur.
Photosensitive skin reactions have been reported. Strong sunlight should be efectos during treatment. Reporting of suspected adverse reactions Reporting suspected adverse reactions after authorisation of the medicinal product is important.
Anticholinergics — Concomitant use of other agents with anticholinergic properties should be undertaken with caution. Pregnancy Tests Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations. Glucose Tolerance Test An increase in blood glucose has been reported in patients receiving promethazine HCl.
It should be used with caution in persons with seizure disorders or in persons who are using concomitant medications, such as narcotics or local anesthetics, which may also affect seizure threshold.
Leukopenia and efectos have been reported, usually when promethazine HCl has been used in association with other known marrow-toxic agents. Neuroleptic Malignant Syndrome A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome NMS has been reported in association with promethazine Phenergan alone or in combination with phenergan drugs. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability irregular secundarios or blood pressure, tachycardiaphenergan 50 mg efectos secundarios, diaphoresis and cardiac dysrhythmias, phenergan 50 mg efectos secundarios.
The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to efectos cases where the clinical presentation includes both serious medical illnesses e. Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat strokedrug fever and primary central nervous system CNS pathology. The management of NMS should include 1 immediate discontinuation of promethazine HCl, antipsychotic drugs, if any, and other drugs not essential to concurrent therapy, 2 intensive symptomatic treatment and medical monitoring, phenergan 50 mg efectos secundarios, and 3 treatment of any concomitant serious medical problems for which specific treatments are available.
There is no general agreement about secundarios pharmacological treatment regimens for uncomplicated NMS.
Since recurrences of NMS have been phenergan with phenothiazines, phenergan 50 mg efectos secundarios, the reintroduction of promethazine HCl should be carefully considered. Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine HCl secundarios pediatric patients.
In pediatric patients efectos are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl.
Other Considerations Administration of promethazine HCl has been associated with reported cholestatic jaundice. Phenergan Promethazine HCl Suppositories should be used cautiously in persons with cardiovascular disease or with impairment of liver function.
Carcinogenesis, Mutagenesis, Impairment Of Fertility Long-term animal studies have not been performed to assess the carcinogenic potential of promethazine, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility with this drug. Promethazine was nonmutagenic in the Salmonella test system of Ames.
Pregnancy Teratogenic Effects Pregnancy Category C Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6. These doses are from approximately 2.
Specific studies to test the action of the drug on parturitionphenergan 50 mg efectos secundarios, lactation, and development of the animal neonate were not done, but a general preliminary study in rats indicated no effect on phenergan parameters.
Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological secundarios of histamine in the rodent do not parallel those in man. There are no adequate phenergan wellcontrolled studies of Phenergan Promethazine HCl Suppositories in pregnant women. Alcohol efectos marijuana can make you more dizzy or drowsy.
Do not drive, use machinery, or do anything that needs secundarios or clear vision until you can do it safely. Talk to your doctor if you are using marijuana. Before having surgery, tell your doctor or dentist about all the products you efectos including prescription drugsnonprescription drugs, and herbal products.
This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps.
Use sunscreen and wear protective clothing when outdoors. This medication may make you sweat less, making you more likely to get heat stroke.
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