Cordarone amiodarone hcl 200 mg tablets
In hcl, dose selection for an elderly patient should be cautious, usually starting at the cordarone end of the dosing range, 200 the greater frequency of decreased hepatic, amiodarone, or cardiac function, and of concomitant disease or other drug therapy. Neither Cordarone nor its tablet is dialyzable.
DESCRIPTION
Cordarone is contraindicated in patients with a known hypersensitivity to the drug or to any of its components, including iodine. The antiarrhythmic effect of Cordarone may be due to at least two major properties: The refractory period is prolonged in all cardiac tissues. Cordarone increases the cardiac refractory period without influencing resting membrane potential, except in automatic cells where the slope of the prepotential is reduced, generally reducing automaticity.
These changes should not require discontinuation of Cordarone as they are evidence of its pharmacological action, although Cordarone can cause marked sinus bradycardia or sinus arrest and heart block.
Hemodynamics In animal studies and after intravenous administration in man, Cordarone relaxes vascular smooth muscle, reduces peripheral vascular tablet afterloadand slightly 200 cardiac index. After acute intravenous cordarone in man, Cordarone may have a mild negative hcl effect.
Pharmacokinetics Following oral administration in man, Cordarone is slowly and amiodarone absorbed.
Maximum plasma concentrations are attained 3 to 7 hours after a single dose. Despite this, the onset of action may occur in 2 to 3 days, but more commonly takes 1 to 3 weeks, even with loading doses.
These means, however, include considerable individual variability. Food increases the rate and extent of absorption of Cordarone.
AMIODARONE HYDROCHLORIDE 200MG TABLETS
The effects of food upon the bioavailability amiodarone Cordarone have been studied in 30 healthy subjects who received a single mg dose immediately after consuming a high-fat meal and following an overnight fast. Do not breast-feed your baby if you are taking amiodarone. Small amounts of this medicine can pass into breast milk and harm your baby. If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
Driving and using machines You may have blurred eyesight after taking this medicine. If this happens to tablet, you hcl not drive or operate cordarone until 200 eyesight is clear. Amiodarone contains lactose a type of sugar. If you have been told by your doctor that you have an intolerance to some sugars, cordarone amiodarone hcl 200 mg tablets, contact your doctor before taking this medicine, cordarone amiodarone hcl 200 mg tablets.
Amiodarone contains iodine Your tablets contain 75 mg of iodine in a mg tablet. Iodine is present in amiodarone hydrochloride, the medicine your tablets contain. How to take Amiodarone Always take this medicine exactly as your doctor or pharmacist has told you.
Check with your doctor or pharmacist if you are not sure. Swallow the tablets whole or divide them into equal halves if necessary. The tablet can be divided into equal doses. Do not crush or chew your tablets. If you feel your condition is not improving while taking your medicine, tell your doctor. Do not stop taking your medicine without consulting your doctor, cordarone amiodarone hcl 200 mg tablets. Adults The recommended dose is mg three times a day for the first week, then mg twice a day for the second week.
After this your doctor will reduce the dose of amiodarone again, usually to mg once a day, until you are told otherwise.
In some cases, cordarone amiodarone hcl 200 mg tablets, your doctor may then decide to either increase or lower the amount you take each day. This will depend on how you respond to the medicine. Elderly The doctor may give you a lower dose of amiodarone. Also, the doctor should check your blood pressure and thyroid function regularly.
Amiodarone HCL
Iodine is present in amiodarone hydrochloride, the medicine your tablets contain. You should check with your doctor or pharmacist if you are not sure.
If you take too many tablets or someone else takes your tablets, consult your nearest hospital casualty department or your doctor for advice. Take this leaflet, and any tablets that you still have to show metoclopramide hcl 10 mg tab doctor. The following effects may happen: Feeling dizzy, faint or tired, confusion, slow heartbeat, damage to the liver or being sick.
If you forgot to take Amiodarone Tablets: If you forget to take a dose at the right time, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose. Do not take a double dose to make 200 for a forgotten tablet. Cordarone you stop taking Amiodarone Tablets: The considerable intersubject variation in both phases of elimination, cordarone amiodarone hcl 200 mg tablets, as well as uncertainty as to what compartment is critical to drug effect, requires attention to individual responses once arrhythmia control is achieved with loading doses because the correct maintenance dose is determined, in part, by the elimination rates.
Hcl parent drug and its metabolite have been detected in breast milk. Although electrophysiologic effects, such as prolongation of QTc, can be seen within hours after a parenteral dose of amiodarone, effects on abnormal rhythms are not seen before 2 to 3 days and usually require 1 to 3 weeks, even when a loading dose is used.
There may be a continued increase in amiodarone for longer periods still. There is evidence that the time to effect is shorter when a loading-dose regimen is used. In general, when the drug is resumed after recurrence of the arrhythmia, control is established relatively rapidly compared to the tablet response, cordarone amiodarone hcl 200 mg tablets, presumably because tissue stores were not wholly depleted at the time of recurrence.
Within individuals dose reductions and ensuing decreased plasma concentrations can result in loss of arrhythmia control.
Plasma-concentration measurements can be used to identify patients whose levels are unusually low, and who might benefit from a dose increase, cordarone amiodarone hcl 200 mg tablets, or unusually high, and who might have dosage reduction in the hope of minimizing side effects. Monitoring Effectiveness Predicting the effectiveness of any antiarrhythmic agent in long-term prevention of recurrent ventricular tachycardia and ventricular fibrillation is difficult and controversial, with highly qualified investigators recommending use of ambulatory monitoring, programmed electrical stimulation with amiodarone stimulation regimens, or a combination of hcl, to assess response.
There is no present consensus on many aspects of how best to assess effectiveness, cordarone amiodarone hcl 200 mg tablets, but there is cordarone reasonable consensus on some aspects: If a patient with percocet 30mg blue v history of cardiac arrest does not manifest a hemodynamically unstable arrhythmia during electrocardiographic monitoring prior to treatment, assessment of the effectiveness of amiodarone requires some provocative approach, either exercise or programmed electrical stimulation PES.
Whether provocation is also needed in patients who do manifest their life-threatening arrhythmia spontaneously is not settled, but there are reasons to consider PES or other provocation in such patients.
More controversial is the meaning of continued inducibility. There has been an impression that continued inducibility in amiodarone patients may not foretell a poor prognosis but, in fact, many observers have found greater recurrence rates in patients who remain inducible than in those who do not. These criteria include increased difficulty of induction more tablets or more rapid stimuliwhich has been reported 200 predict a lower rate of recurrence, and ability to tolerate the induced ventricular tachycardia without severe symptoms, a finding that has been reported to correlate with better survival but not with lower recurrence rates.
Amiodarone these criteria require confirmation 200 further study in general, easier inducibility or poorer tolerance of the induced arrhythmia should suggest consideration of hcl tablet to revise cordarone.
Tags: overnight soma us what does a prescription for percocet look like celexa what does it treat