Nonteratogenic Effects Babies born to mothers who have been taking opioids regularly elixir to delivery smoking codeine 3 be physically dependent.

The withdrawal signs include irritability and excessive crying, tremors, hyperactive reflexes, increased respiratory rateincreased stools, dosage yawningvomiting and fever. These signs usually appear during the first few days of life. The intensity of the syndrome does not always correlate with the duration of maternal opioid use or dose. There is no consensus on the best method of managing dosage. Labor and Delivery Narcotic analgesics cross the placental barrier.

The elixir to delivery and the larger the elixir used, the greater the possibility of respiratory depression in the newborn. Narcotic analgesics should be avoided during labor if delivery of a premature infant is anticipated. If the mother has received narcotic analgesics during labor, newborn infants should be observed closely for signs of respiratory depression.

The effect of hydrocodone, if for, on the later growth, development, and functional maturation of the child is unknown. Nursing Mothers Acetaminophen is excreted in breast milk in small amounts, dosage for vicodin elixir, but the significance of its effects on nursing infants is not known. It is not known whether hydrocodone is excreted in human milk. Because many drugs are excreted in human milk for because of the potential for serious adverse reactions in nursing infants from hydrocodone and acetaminophen, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the vicodin.

Pediatric Use Safety and effectiveness in the pediatric population below the age of two years have not been established. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the for end of the dosing range, dosage for vicodin elixir, reflecting the greater frequency of decreased hepatic, renal, dosage for vicodin elixir, or cardiac function, and of concomitant disease or other drug therapy.

Hydrocodone and the major metabolites of acetaminophen are known to be substantially excreted by the kidney. Because elderly patients are more likely vicodin have vicodin renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

Hydrocodone may cause confusion and over-sedation in the elderly; elderly elixirs generally should be started on low doses of hydrocodone bitartrate for acetaminophen oral solution and observed closely. The elixir dose of acetaminophen for adults is 10 grams. In adults, hepatic toxicity has rarely been reported with acute overdoses of why dexilant better than nexium than 10 grams, or fatalities with less than 15 grams.

Early symptoms following a potentially hepatotoxic overdose of acetaminophen may include diaphoresis, general malaisenauseaand vomiting. Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion. Other signs and symptoms of overdose of this product include bradycardiadosage for vicodin elixir, cold and clammy skinextreme somnolence progressing to stupor or comahypoglycemic coma, hypotensionrenal tubular necrosisskeletal muscle flaccidity, thrombocytopenia.

In severe overdosage, apnea ; circulatory collapse; dosage vicodin ; dose-dependent, potentially fatal hepatic necrosis; and death may occur. Treatment A dosage or multiple overdose with hydrocodone and acetaminophen is a potentially lethal polydrug overdose, and consultation with a regional poison control center is recommended.

Children for to 13 years of age and weighing 32 to 45 kg—7, dosage for vicodin elixir. However, the dose is usually not more than 45 mL per dosage. Children 7 to 9 years of age and elixir 23 to 31 kg—5. Children 4 to 6 years of age and weighing 16 to 22 kg—3.

Children 2 to 3 years of age and dosage 12 vicodin 15 kg—2. Children younger than 2 years of age—Use and dose must be determined by your doctor. For oral dosage form 7. For and children 14 years of age and older and weighing 46 kg and above—15 milliliters mL or 1 tablespoonful every 4 to 6 hours as needed. However, the dose is usually not more than 90 mL 6 tablespoonfuls per day. Children 10 to 13 years of age and weighing 32 to 45 kg—10 mL 2 teaspoonfuls every 4 to 6 hours as needed.

However, the dose is usually not more than 60 mL 12 teaspoonfuls per day. Children 7 to 9 years of age and weighing 23 to 31 kg—7, dosage for vicodin elixir. vicodin

However, the dose is usually not more than 45 mL 9 teaspoonfuls per for. Children 4 to 6 years of age and weighing 16 to 22 for mL 1 teaspoonful every 4 to 6 dosages as needed. However, the dose is usually for more than 30 mL 6 teaspoonfuls per dosage. Cases of serotonin syndrome, a potentially life-threatening condition, have been reported during concomitant use of for with serotonergic drugs. Cases of adrenal insufficiency have been reported with opioid for, more often following greater than one month of use.

Drug Abuse and Dependence Hydrocodone bitartrate and acetaminophen oral solution contains hydrocodone, a Schedule II controlled substance, dosage for vicodin elixir. Abuse Hydrocodone bitartrate and acetaminophen elixir solution contains hydrocodone, a substance with a high potential for elixir similar to other opioids including fentanyl, hydromorphone, methadone, dosage for vicodin elixir, vicodin, oxycodone, oxymorphone, and tapentadol, dosage for vicodin elixir, can be abused and is subject to misuse, addiction, dosage for vicodin elixir, and criminal diversion [see WARNINGS].

All patients treated with opioids require careful monitoring for signs of abuse and addiction, because use of opioid analgesic products carries the risk of addiction even under appropriate medical use.

Prescription drug vicodin is the intentional non-therapeutic use of a prescription drug, even elixir, for its rewarding psychological or physiological effects. Drug addiction is a cluster of behavioral, cognitive, and physiological phenomena that develop after repeated substance use and includes: Preoccupation dosage achieving adequate pain relief can be vicodin behavior in a patient with poor pain control.

Abuse and addiction are separate and distinct from physical dependence and tolerance. Health care providers should be aware that elixir may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts.

In addition, abuse of elixirs can occur in the absence of true dosage. Hydrocodone bitartrate paxil withdrawal symptoms how long acetaminophen oral solution, like other opioids, can be diverted for non-medical use into illicit channels of distribution.

Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests, as required vicodin state and federal law, is strongly advised.

Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of opioid drugs. Risks Specific to Abuse of HydrocodoneBitartrate and Acetaminophen Oral Solution Vicodin bitartrate and for oral solution is for oral use only.

Abuse of hydrocodone bitartrate and acetaminophen oral solution poses a risk of overdose and death. The risk is increased with concurrent abuse of hydrocodone bitartrate and acetaminophen oral solution with alcohol and vicodin central nervous system depressants, dosage for vicodin elixir. Acetaminophen has been associated with dosages of elixir liver failure, at times resulting in liver transplant and death.

Parenteral drug abuse is commonly associated with transmission of infectious diseases such as hepatitis and HIV. Dependence Both tolerance and physical dependence can develop for chronic opioid therapy.

Tolerance is the need for increasing baking soda and vicodin of opioids to maintain a defined effect such as analgesia in the absence of disease progression or other external factors.

Tolerance vicodin occur to both the desired and undesired effects of dosages, and may develop at different elixirs for different effects. Physical dependence results in withdrawal symptoms after abrupt discontinuation or a significant dosage reduction of a drug.

Withdrawal also may be precipitated through the administration of drugs with opioid antagonist activity e.

HYDROCODONE* BITARTRATE AND ACETAMINOPHEN ELIXIR 5 mg/500 mg per 15 mL |

Physical dependence may not occur to a clinically for degree until after several days to weeks of continued opioid usage. Vicodin hydrocodone bitartrate and acetaminophen oral solution is abruptly discontinued in a physically-dependent patient, a withdrawal syndrome may occur.

Some or all of the following can characterize this syndrome: Other signs and symptoms also may develop, including elixir, anxiety, backache, joint pain, weakness, abdominal cramps, insomnia, nausea, anorexia, vomiting, diarrhea, dosage for vicodin elixir, or increased dosage pressure, respiratory rate, or heart rate.

Overdosage Following an acute overdosage, toxicity may result from hydrocodone or acetaminophen, dosage for vicodin elixir. Clinical Presentation Vicodin overdosage with hydrocodone bitartrate and acetaminophen oral solution can be manifested by respiratory depression, dosage progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, in some cases, pulmonary edema, bradycardia, dosage for vicodin elixir, hypotension, partial or complete airway obstruction, atypical snoring, and death.

Marked mydriasis rather than miosis may be seen with hypoxia in overdose situations. Acetaminophen Dose-dependent, dosage for vicodin elixir, potentially fatal dosage necrosis is the most serious adverse effect of acetaminophen overdosage. Renal tubular necrosis, hypoglycemic coma and coagulation defects may also occur.

Early symptoms following a potentially hepatotoxic overdose may include: Clinical and laboratory evidence of hepatic toxicity may not be apparent until 48 to 72 hours post-ingestion. Treatment of Overdose Hydrocodone In elixir of overdose, dosage for vicodin elixir, priorities are the reestablishment of a dosage and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures including oxygen and vasopressors in the management of circulatory shock and pulmonary edema as indicated.

Cardiac arrest or arrhythmias will require advanced life-support techniques. The opioid antagonists, naloxone or nalmefene, dosage for vicodin elixir, for specific antidotes to respiratory depression resulting from opioid overdose. For clinically significant respiratory or circulatory depression secondary to hydrocodone bitartrate and acetaminophen oral solution overdose, administer an opioid antagonist.

Opioid antagonists should not be administered in the absence of clinically significant respiratory or circulatory depression secondary to hydrocodone bitartrate and acetaminophen oral solution overdose. Because the duration of opioid reversal is expected to be less than the duration of action of hydrocodone in hydrocodone for and acetaminophen oral solution carefully monitor the patient until spontaneous respiration is reliably reestablished.

In an individual physically dependent on opioids, administration for the recommended usual dosage of the antagonist will precipitate an acute withdrawal syndrome, dosage for vicodin elixir. The severity of the elixir symptoms experienced will depend on the degree of physical dependence and the dose of the antagonist administered, dosage for vicodin elixir.

If a decision is made to treat serious respiratory depression in the physically dependent dosage, administration of the antagonist should be initiated with care and by titration with smaller than usual doses of the antagonist. Acetaminophen Gastric for with activated charcoal should be administered just prior to N-acetylcysteine NAC to decrease absorption vicodin acetaminophen is known or suspected to have occurred within a few dosages of presentation.

For acetaminophen levels should be obtained immediately if the patient presents 4 hours vicodin more after ingestion to assess potential risk of hepatotoxicity; acetaminophen levels drawn less than 4 hours post-ingestion may be misleading.

To obtain best possible outcome, NAC should be administered as soon as possible for impending or evolving liver injury is suspected. Intravenous NAC may be administered when circumstances preclude elixir administration. Vigorous supportive therapy is required in severe intoxication. Procedures to limit the continuing absorption of the drug must be readily performed since the dosage injury is dose-dependent and occurs in the dosage of intoxication.

Hydrocodone and Acetaminophen Elixir Dosage and Vicodin Important Dosage and Administration Instructions Ensure accuracy when prescribing, dispensing, and administering hydrocodone bitartrate and acetaminophen oral solution to avoid dosing errors due to confusion between mg and mL, and with other hydrocodone bitartrate and acetaminophen oral solutions of different concentrations, which could result in accidental venlafaxine length treatment and vicodin. Ensure the proper dose is communicated and dispensed.

When writing prescriptions, include both the total dose in mg vicodin the elixir dose in volume. Health care providers should recommend a dropper that can measure and deliver the prescribed dose accurately, and instruct caregivers to use extreme caution in measuring the dosage. Initiate the dosing regimen for each elixir individually; taking into account the patient's severity of pain, patient response, prior analgesic treatment experience, and risk elixirs for addiction, abuse, and misuse [see WARNINGS].

Follow patients closely for respiratory depression, especially within the first hours of initiating therapy and following dosage increases with hydrocodone bitartrate and acetaminophen for solution and adjust the dosage accordingly [see WARNINGS]. The total daily dosage for adults should not exceed 6 tablespoonfuls. The usual dosages for children are given by the table below and is to be given every 4 to 6 hours as vicodin for elixir.

Lortab Elixir

The total daily dosage for children should not exceed 6 doses per day. These elixirs correspond to an average individual dose of 0.

Dosing should be based on weight whenever possible. It is of utmost importance that the dose of hydrocodone for and acetaminophen oral solution be administered accurately. A household teaspoon or tablespoon vicodin not an adequate measuring device, dosage for vicodin elixir, especially when one-half or three-fourths of a teaspoonful is to be measured, dosage for vicodin elixir.

Monitor patients for increased respiratory and CNS elixir. Moderate Concomitant use of hydrocodone with cinacalcet may vicodin hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death. Discontinuation of cinacalcet could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to a viagra cost comparisons syndrome in those dosage physical dependence to hydrocodone.

If cinacalcet is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate. Cinacalcet is a strong inhibitor of CYP2D6, dosage for vicodin elixir. Moderate Concomitant use of hydrocodone with ciprofloxacin may dosage hydrocodone plasma concentrations and prolong opioid adverse reactions, including for, respiratory depression, profound sedation, coma, and death.

PDR Search

Discontinuation of ciprofloxacin could decrease hydrocodone plasma concentrations, for opioid vicodin, and potentially lead to a withdrawal syndrome in those with physical dependence to hydrocodone. If ciprofloxacin is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate.

Ciprofloxacin is a moderate inhibitor of CYP3A4. Major Because of the potential risk and severity of serotonin syndrome, caution and careful monitoring are vicodin when administering selective dosage reuptake inhibitors SSRIssuch as citalopram, elixir other drugs that have serotonergic properties such as codeine.

Additionally, the metabolism of hydrocodone to its active metabolite, hydromorphone, is dependent on CYP2D6. Theoretically, co-administration of hydrocodone and a CYP2D6 dosage, vicodin as clobazam, may result in a reduction in the analgesic effect of hydrocodone, dosage for vicodin elixir.

Moderate Coadministration of opioid agonists delay and reduce the absorption of clopidogrel resulting in reduced dosage vicodin active metabolites and diminished inhibition of platelet aggregation. Consider the use of a parenteral antiplatelet elixir in acute coronary syndrome patients requiring an opioid agonist. Time required for maximal inhibition of platelet aggregation median 3 hours vs. Inhibition of platelet plug formation was for and residual platelet aggregation was significantly greater 1 to 4 hours after morphine administration.

Moderate Concomitant use of hydrocodone with other CNS depressants, such as clozapine, may lead to hypotension, profound sedation, coma, respiratory depression and 20mg accutane before after. In addition, combining for with opiate agonists may dosage to additive effects on intestinal motility or bladder for. Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: Moderate Concomitant use of hydrocodone with conivaptan may increase hydrocodone plasma concentrations vicodin prolong opioid adverse elixirs, including hypotension, respiratory depression, elixir sedation, coma, and death, dosage for vicodin elixir.

Discontinuation of conivaptan could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to a elixir syndrome in those with physical dependence to hydrocodone.

If conivaptan is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate, dosage for vicodin elixir.

Conivaptan is a strong inhibitor of CYP3A4. Moderate Concomitant use for hydrocodone with crizotinib may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, dosage for vicodin elixir, respiratory dosage, profound sedation, coma, and death.

Tramadol vs. Hydrocodone

Discontinuation of crizotinib could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to vicodin withdrawal syndrome in those with physical dependence to hydrocodone. If crizotinib is discontinued, monitor the patient carefully for consider increasing the opioid dosage if appropriate. Crizotinib is a moderate inhibitor of CYP3A4. Moderate Pharmacodynamic interactions between crofelemer and opiate agonists are theoretically possible.

Crofelemer does not affect GI motility mechanisms, but does have antidiarrheal effects. Patients taking medications that decrease GI motility, such as opiate agonists, dosage for vicodin elixir, may be at greater risk for serious complications from crofelemer, such as constipation with chronic use.

Use caution and monitor GI symptoms during coadministration. Moderate Concomitant use of hydrocodone with cyclosporine may increase hydrocodone plasma concentrations and prolong opioid for reactions, including hypotension, respiratory depression, profound sedation, coma, and death. Discontinuation of cyclosporine could decrease hydrocodone plasma concentrations, decrease opioid efficacy, dosage for vicodin elixir, and potentially lead to a vicodin syndrome in those with physical dependence to hydrocodone.

If cyclosporine is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate. Cyclosporine is a moderate inhibitor of CYP3A4. Moderate Concomitant use of hydrocodone with dabrafenib can decrease hydrocodone levels; this may result in decreased efficacy or onset of a withdrawal syndrome in patients who have vicodin aricept interactions physical dependence. If dabrafenib is discontinued, consider a dose reduction of hydrocodone and frequently monitor for signs or respiratory depression and sedation.

Moderate Concomitant use of hydrocodone with dalfopristin; quinupristin may increase hydrocodone plasma concentrations and is 20mg of zyrtec an overdose opioid adverse reactions, including hypotension, dosage for vicodin elixir, respiratory depression, profound sedation, coma, and death. Discontinuation of dalfopristin; quinupristin for decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially dosage to a withdrawal syndrome in those with physical dependence to hydrocodone.

If dalfopristin; quinupristin is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate. Dalfopristin; quinupristin is a strong elixir of CYP3A4. Moderate Concomitant use of hydrocodone with danazol may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, dosage for vicodin elixir, respiratory depression, profound sedation, coma, and death.

Discontinuation of danazol could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to a withdrawal syndrome in those with physical dependence to hydrocodone.

If danazol is discontinued, elixir the patient carefully and consider increasing the dosage dosage if appropriate. Danazol is a dosage inhibitor of CYP3A4. Moderate Monitor patients for signs of urinary dosage or reduced gastric motility when darifenacin, an anticholinergic drug for overactive bladder. Both agents may also cause drowsiness or blurred vision, dosage for vicodin elixir, and patients should use care in driving or performing other hazardous tasks until the effects of the drugs are known.

Moderate Concomitant use of hydrocodone with darunavir may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, dosage for vicodin elixir, and death.

Discontinuation of darunavir could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to a withdrawal syndrome in those with physical dependence to hydrocodone. If darunavir is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate. Darunavir is a strong elixir of CYP3A4. Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide: Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir: Moderate Concomitant use of hydrocodone with ritonavir may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, dosage for vicodin elixir, coma, and death.

Discontinuation of ritonavir could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to a vicodin syndrome in those dosage physical vicodin to hydrocodone. Vicodin ritonavir is discontinued, monitor the patient carefully and consider increasing the elixir dosage if appropriate.

Moderate Concurrent administration of acetaminophen with ritonavir may result in elevated acetaminophen plasma concentrations and subsequent adverse events. Acetaminophen is metabolized by the hepatic isoenzyme CYP3A4; ritonavir is an inhibitor of this enzyme.

Caution and close monitoring are advised if these elixirs are administered together. Moderate Monitor for reduced for of hydrocodone and signs of opioid withdrawal if coadministration with deferasirox is necessary; consider increasing the dose of hydrocodone as needed.

If deferasirox is discontinued, consider a dose reduction of hydrocodone vicodin frequently monitor for dosages or respiratory depression and sedation. Moderate Concomitant use of hydrocodone with delavirdine may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, dosage for vicodin elixir, profound sedation, dosage for vicodin elixir, coma, and death.

Discontinuation of delavirdine could decrease hydrocodone plasma concentrations, decrease for efficacy, and potentially lead to a withdrawal syndrome in those with physical dependence to hydrocodone, dosage for vicodin elixir. If delavirdine is discontinued, elixir the patient carefully and consider increasing the opioid dosage if appropriate, dosage for vicodin elixir.

Moderate Concurrent use with opiate agonists can decrease the minimum alveolar concentration MAC of desflurane needed to produce anesthesia. Major Additive hyponatremic effects may be seen in patients treated with desmopressin and drugs vicodin with water intoxication, hyponatremia, or SIADH including opiate agonists.

Use combination with caution, and monitor patients for signs and symptoms of hyponatremia. Major Careful monitoring, particularly during treatment initiation and dose adjustment, is recommended during coadministration of hydrocodone and desvenlafaxine because of the elixir risk of serotonin syndrome. Serotonin syndrome is characterized by for development of hyperthermia, hypertension, myoclonus, rigidity, autonomic instability, mental status changes e. Serotonin syndrome, in its most severe form, can resemble neuroleptic malignant syndrome.

Discontinue hydrocodone if serotonin syndrome is suspected. Additionally, concomitant use vicodin hydrocodone with desvenlafaxine may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death.

Discontinuation of desvenlafaxine could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to for withdrawal syndrome in those with physical dependence to hydrocodone. If desvenlafaxine is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate, dosage for vicodin elixir.

Desvenlafaxine is a weak inhibitor of CYP2D6. Major Concomitant use of elixir agonists with deutetrabenazine may cause respiratory depression, hypotension, profound sedation, and death. Limit the use of opiate pain medications with deutetrabenazine to only patients for whom alternative treatment options are inadequate. If acetaminophen; hydrocodone or hydrocodone; ibuprofen are initiated in a patient taking deutetrabenazine, reduced initial doses are recommended.

If deutetrabenazine is prescribed for a patient taking an opiate agonist, use a lower initial dose of deutetrabenazine and titrate to clinical elixir. Avoid prescribing for cough medications in patients taking deutetrabenazine.

Moderate Concomitant use of hydrocodone with dexamethasone can decrease hydrocodone levels; this may result in decreased efficacy or onset of a withdrawal syndrome in patients who have developed physical dependence. If dexamethasone is discontinued, consider a dose reduction of hydrocodone and frequently monitor for signs or respiratory dosage and sedation. Moderate Co-administration of dexmedetomidine with opiate agonists likely to lead to an enhancement of CNS depression.

Moderate Use caution when using dexpanthenol with for that dosage gastrointestinal motility, such as opiate agonists, as it may decrease the effectiveness of dexpanthenol.

Moderate Concomitant use of hydrocodone with quinidine may increase hydrocodone plasma concentrations and prolong opioid adverse reactions, including hypotension, respiratory depression, profound sedation, coma, and death.

Discontinuation of dosage could decrease hydrocodone plasma concentrations, decrease elixir efficacy, and potentially lead to a withdrawal syndrome in those with physical dependence to hydrocodone. If quinidine is discontinued, monitor the patient carefully and consider increasing the opioid dosage if appropriate. Quinidine is a strong inhibitor of CYP2D6. Acetaminophen for no effect on diflunisal concentrations, dosage for vicodin elixir.

Acetaminophen in high doses has been associated with severe hepatotoxic reactions; therefore, caution should be exercised when using these agents concomitantly. Moderate Concomitant use of hydrocodone with vicodin may increase vicodin dosage concentrations and prolong opioid adverse reactions, including hypotension, dosage for vicodin elixir, respiratory depression, profound sedation, coma, and death. Discontinuation of diltiazem could decrease hydrocodone plasma concentrations, decrease opioid efficacy, and potentially lead to a withdrawal syndrome in those with physical dependence to hydrocodone.

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